Psilocybin Mushroom Research | Science

Psilocybin

Psilocybin, the active ingredient in psychoactive mushrooms, has provided the spiritual and cultural bedrock of many great civilisations. The Aztecs referred to teonanácatl, which translates as ‘divine mushroom’, and modern neuroscience has revealed how psilocybin interacts with serotonin receptors in the brain in order to produce a range of consciousness-altering effects.

Our research with Psilocybin

Beckley/Imperial:

The first human fMRI study with psilocybin: an invaluable data pool to elucidate the changes in brain networks dynamics induced by psychedelics
The ground breaking pilot clinical trial investigating the therapeutic potential of psilocybin-assisted therapy for treatment-resistant depression
How long do the positive effects of psilocybin last for? Six-months follow-up study

Beckley/Johns Hopkins:

Using psilocybin-assisted therapy to quit smoking: a proof of concept study

Beckley/Maastricht:

Beyond the 5HT2A receptor: Shedding light on the mechanisms underlying ego-dissolution

Psilocybin Highlights

Psilocybin for Depression

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

Support Psilocybin Research

Ongoing and Planned Studies

Mechanisms of action of psilocybin

Psilocybin for Smoking Cessation

Published Papers of Completed Studies

Psilocybin and Depression

Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms, 2017

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up, 2017

Psilocybin with psychological support improves emotional face recognition in treatment-resistant depression, 2017

Psilocybin increases communication between brain networks to a greater extent than MDMA – Frontiers in Human Neuroscience, 2014

Homological Scaffolds of Brain Functional Networks - Royal Society Interface, 2014

Brain ‘entropy’ or disorder may underlie the psychedelic state and inform an understanding of normal waking consciousness – Frontiers in Human Neuroscience, 2014

Broadband Cortical Desynchronization Underlies the Human Psychedelic State - Journal of Neuroscience, 2013

Neuroimaging reveals how psilocybin modulates activity in the human brain – PNAS, 2012

Psilocybin for Smoking Cessation

Pilot study for psilocybin-assisted psychotherapy as a treatment for tobacco addiction – Journal of Psychopharmacology, 2014

Mystical experience may be a key part of successful psilocybin-assisted treatment of addiction – Current Drug Abuse Reviews, 2014

Psilocybin and Brain Function

Psilocybin facilitates the recollection of positive personal memories – The British Journal of Psychiatry, 2012

Psilocybin’s transient effect on brain network connectivity may resemble that of early psychosis – Schizophrenia Bulletin, 2013

Subjective Experience and Tolerability Under Psilocybin

Finding the self by losing the self: Neural correlates of ego dissolution under psilocybin – Human Brain Mapping, 2015

Subjective reports of participant experiences under psilocybin in an MRI scanner – Current Drug Abuse Reviews, 2014

Psilocybin can be safely administered in a brain imaging environment – Journal of Psychopharmacology, 2010

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