It is thought that the entactogen and empathogen effects of MDMA can be harnessed to aid in psychotherapy for fear- and mood-based disorders. Not only can MDMA facilitate trust and acceptance towards others, thereby decreasing fear and defensiveness towards practitioners, but it also increases self-acceptance, which can play an important role in psychotherapy.

Studies investigating the effectiveness of MDMA for Post-Traumatic Stress Disorder (PTSD) have demonstrated excellent results, both in the short- and long-term. The benefits of MDMA-assisted psychotherapy persist years after the first treatment with the drug, giving hope to people with PTSD who do not respond to conventional treatments.