Potential analgesic effects of psychedelics on select chronic pain conditions: A survey study

Mauro Cavarra, Natasha Leigh Mason, Kim P C Kuypers, Valerie Bonnelle, Will J Smith, Amanda Feilding, Pamela Kryskow, Johannes G Ramaekers

Chronic pain is a major cause of suffering and disability and is often associated with psychiatric complications. Current treatments carry the risk of severe side effects and may lead to limited or no relief at all in a relevant portion of this patient population. Preliminary evidence suggests that classical psychedelics (e.g. LSD and psilocybin) may have analgesic effects in healthy volunteers, and in certain chronic pain conditions and observational studies reveal that they are used in naturalistic settings as a means to manage pain.

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