[Article in Russian]
Authors: Moskalenko YE, Vainshtein GB, Halvorson P, Kravchenko TI, Feilding A, Riabchikova NA, Semernia VN, Panov AA.
Biomechanical properties of the human skull affect its dynamic tensility (pliability, compliance) by changes of intracranial volume and pressure (deltaV/deltaP). The goal of this study is to substantiate a possibility of noninvasive and dynamic evaluation of cranial compliance. The transcranial dopplerogram of middle cerebral artery and hemispheric bioimpedance were synchronously recorded, which represent information about pulsative changes of intracranial pressure and volume, respectively. The parameters were recorded at rest and during adequate hemo- and liquorodynamic tests in different age groups–20-30, 40-50, and 70-85 years. As compared with the young group, a decrease of the cranial compliance in the intermediate age group was revealed due to an observed increase if rigidity of skull bones and ligaments, which indicates a decrease of stability of the intracranial circulatory system. However, in the group of 70-85 years the compliance rose again due to an enlargement of intracranial liquor spaces and facilitation of liquor circulation inside the intracranial cavity; this can be suggested to be a compensatory mechanism for supporting the adequate brain circulatory-metabolic state.
Psilocybin for Depression
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