Beckley Foundation - Sechenov Institute Collaboration

The Effect of Craniotomy on the Intracranial Hemodynamics and Cerebrospinal Fluid Dynamics in Humans

After 10,000 years we are delighted to announce the results of the first scientific investigation into the physiological effects of trepanation, the oldest surgical procedure in the world. Read the fascinating findings on how a skull opening changes the pattern of cerebral circulation and can restore lost circulation in those suffering cerebral insufficiency.

Relation of Age Cognitive Disorders With Cranial Compliance, Cerebrospinal Fluid Mobility and Cerebral Circulation;

Moskalenko Y.E., Weinstein G., Feilding A., Halvorson P., Riabchikova N., Kravchenko T., Panov A. Semernia V. International Journal of Psychophisiology. v.69, 2008 PP: 276-316.

Already Published 

1. Age related peculiarities of ratio of parameters of functioning of hemo- and liquorodynamics systems.

Yu. E. Moskalenko, G. B. Weinstein, P. Halvorson, N. A. Ryabchikova, T. I. Kravchenko, A. Feilding, A. A. Panov, V. N. Semernia, and S. P. Markovets. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg, Russia

Journal of Evolutionary Biochemistry and Physiology, 2006, Vol. 42, No. 6, pp. 602-610.

2. Age characteristics of relationships between brain blood flow, liquorodynamics and biomechanical properties of human cranium.

Moskalenko Yu.E., Weinstein G.B., Halvorson P., Kravchenko T.I., Feilding A., Ryabchikova N.A., Semernia V.N., Panov A.A. Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Acad. Sci. St.Petersburg, Russia.

Russian Journal of Physiology. 2007. v.93. n.7. p.788-798.

3. Slow wave fluctuations in cranio-sacral space: hemo- liquorodynamic conception of origin.

Moskalenko Yu.E., Kravchenko T.I., Weinstein G.B., Halvorson P., Feilding A., Mandara A., Panov A.A., Semernia V.N. I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci.

Russian Journal of Physiology 2008 v.94 n.4 p.441-447.

4. Biomechanical properties of human cranium: ageing aspects.

Moskalenko Yu.E., Weinstein G.B., Halvorson P., Kravchenko T.I., Ryabchikova N.A., Feilding A., Semernia V.N., Panov A.A Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Acad.Sci., St.Petersburg, Russia.

Journal of Evolutionary Biochemistry and Physiology, 2008, Vol. 44, No. 5, pp.513-520.

5. Liquorodynamic and hemodynamic effects of cranial trepanation.

Yu.E. Moskalenko, G.B. Weinstein, T.I. Kravchenko, S.V. Mozhaev, Riabchikova N.A., A. Feilding, P. Halvorson, Panov A.A., Medvedev S.V.

Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Acad.Sci., St.Petersburg, Russia, Institute of the Human Brain Russian Acad.Sci., St. Petersburg, Russia, and Beckley Foundation, Oxford, U.K.

Proc. of the All-Russian Conference "The 7 th Prof. A.L.Polenov Readings". St.Petersburg, Russia. 2008. p.62-63.

6. Effect of the skull trephination opening on the interaction between intracranial vascular and CSF systems.

Journal of Neurotrauma, 2006. V.23. N.6. Abstr. P55 p.1000.

7. The Elderly And Old Age Correlation Of Intracranial Hemo - And Liquoro- Dynamics Systems.

Moskalenko Yu.E., Weinstein G.B., Halvorson P., Ryabchikova N.A, Kravchenko T.I., Feilding A., Semernia V.N., Panov A.A., Mayorova N.F., Markovets S.P.

Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Acad. Sci., St. Petersburg, Russia.

Proc. of the Conference "Cerebrovascular pathology in Leningrad Siege survivors and in elderly persons ". St. Petersburg, 2006. p.19-21.

8. Age dependent correlation between cerebral blood circulation, cerebrospinal fluid dynamics and the cranial compliance.

Yu.E. Moskalenko 1 , P. Halvorson 4 , T.I. Kravchenko 2 , G.B. Weinstein 1 , N.A. Ryabchikova 3 , A. Feilding 4 , A.A. Panov 1 Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad.Sci., Laboratory of Cerebral Circulation, St.Petersburg, Russia; 2 Russian School of Osteopathic Medicine, St.Petersburg, Russia 3 Moscow State University, Moscow, Russia;4 Beckley Foundation, Oxford, U.K.

Published in the "Advances in Gerontology". 2007 v.20 n.3 p.58.
(Proc. of the 6 th European Congress of the Intern. Assoc. of Gerontology and Geriatrics St.Petersburg, Russia, 2007).

9. Noninvasive dynamic evaluation of functioning of the intracranial system.

Moskalenko Yu., Weinstein G., Kravchenko T., Feilding A., Halvorson P., Ryabchikova N. Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Acad. Sci., St Petersburg, Russia

10. Relationships between indices of cerebral circulation, liquorodynamics, cranial biomechanics and prognostic brain ability.

Moskalenko Yu., Weinstein G., Ryabchikova N., Kravchenko T., Samus N., Feilding A., Halvorson P., Semernia V.

Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Acad. Sci., St.Petersburg, Russia; Moscow State University, Moscow, Russia; Beckley Foundation, Oxford, UK.

Proc. of the 4 th All-Russian School-Conference on Circulatory Physiology. Moscow, 2008. P.68.

11. Dynamic determination of functional state of mechanism of the circulatory-metabolic supply of human brain activities.

Proc. of the 5 th Internat. Conference "Development and applying of high technologies in science, industry and education". St.Petersburg. 2008. v.12. p.363-367.

12. Effects of Cranial trepanation to functioning of cerebrovascular and cerebro-spinal fluid systems.

Yu. Moskalenko*, G. Weinstein*, T. Kravchenko*, A. Feilding**, P. Halvorson,**

V. Semernia*,A. Panov*, S. Medvedev*** Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, Laboratory of Cerebral Circulation Physiology, St.Petersburg, Russia; Beckley Foundation, Oxford, UK; Institute of the Human Brain RAS, St.Petersburg, Russia

Proc. ]ournal of 14 world Congress on Psychophysiology.Int. J. of Psychophysiol. Abstract 426.

Papers Submitted for Publication:

13. Paper: Relations between cranial compliance, CSF - dynamics and brain blood flow for aging persons with cognitive deasorders.

Moskalenko Yu.E.,*, Riabchikova N.A**., Weinshtein G.B.*., Kravchenko T.I.*, Feidling A.***, Halvorson P.***, Samus N.L*., Semernia, V.N.*, Panov A.A.*, Institute for evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Department of Biology Lomonosov State University, Moscow, Russia; Beckley Foundation, Oxford, UK.

Submitted to Journal 'Regional Blood circulation'

14. Paper: Peculiarities of activity of physiological mechanism, supporting human brain activity of middle aging(40-55) persons.

Moskalenko Yu.E., Riabchikova N.A., Weinstein G.B., Kravchenko T.I., Feilding A., Halvorson P., Samus N.L., Semernia V.N., Panov A.A.; *Institute for evolutionary Physiology and Biochemistry, Russian Academy of Sciences; **Department of Biology Lomonosov State University, Moscow, Russia,; *** Beckley Foundation, Oxford, UK.

Submitted to Journal of Human Physiology.