advancing scientific discovery with evidence-based research

The aim of the Beckley Foundation Scientific Programme is to increase understanding of brain function and consciousness. We use psychoactive substances as tools to alter brain activity. By investigating these changes with the latest brain-imaging technology, we open up exciting new avenues of treatment for physical and mental conditions, and unveil the mechanisms by which psychedelics produce their profound effect. By changing consciousness, we learn more about normal consciousness.

To date, the Beckley Foundation has conducted scientific studies in conjunction with some of the world’s leading academic institutions, including Johns Hopkins, Imperial College, University College London, and King’s College. A summary of the Beckley Foundation Scientific Research Programme is available online by clicking here.

Below is a complete list of Beckley Foundation Scientific publications.

Thumbnail image for Beckley Foundation Collaboration – A theory of conscious states informed by neuroimaging research with psychedelic drugs

Beckley Foundation Collaboration – A theory of conscious states informed by neuroimaging research with psychedelic drugs

February 4, 2014 BF Scientific Publications

Full article on Frontiersin.org This article has argued that scientific research with psychedelic drugs can have a revitalizing effect on psychoanalysis and an informing influence on mainstream psychology and psychiatry. Rather than discuss the content and interpretation of psychoanalytically-relevant material, we have adopted a mechanistic approach, in keeping with the mainstream cognitive neuroscience. This article […]

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Thumbnail image for How Ecstasy Acts on The Brain And Hints at Therapeutic Uses

How Ecstasy Acts on The Brain And Hints at Therapeutic Uses

January 24, 2014 BF Scientific Publications

MDMA is by no means a new substance in the drug landscape. Its recreational use sparked in the 1980s and has been sustained until now. However, veiled by a mix of urban legend, unscrupulous reporting and particularly harsh regulation; its mechanisms of action have remained mostly unknown. One of our goals here at the Beckley […]

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Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

October 15, 2012 BF Scientific Publications

A new analysis of the original psilocybin fMRI data has recently been published in a new paper in Schizophrenia Bulletin, in which the psychedelic state is analysed for similarity with early psychosis, as both share similar effects on how different areas of the brain communicate with eachother.

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Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

October 11, 2012 BF Scientific Publications

Amanda Feilding is one of 14 authors on a new study which supports the idea that high-THC/low-CBD cannabis products are associated with increased risks for mental health. Click the link to download the full PDF from the Journal of Psychopharmacology Click here to download the original article and access the FULL PDF document In this […]

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Press Release: The Beckley Foundation-Imperial College Psychedelic Research Programme

January 26, 2012 Beckley Science in the Media

Press Release 25th January 2012 The Beckley Foundation-Imperial College Psychedelic Research Programme Surprising findings of Research: Potential therapeutic applications of psychedelic drugs fMRI brain scans show that psilocybin, the active ingredient in magic mushrooms, lowers the activity of specific brain regions. The finding contradicts the popular belief that psychedelic drugs increase brain activity, and has […]

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Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin

January 3, 2012 BF Scientific Publications

The subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain’s key connector hubs, enabling a state of unconstrained cognition.

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Implications for psychedelic-assisted psychotherapy: a functional magnetic resonance imaging study with psilocybin

January 3, 2012 BF Scientific Publications

An observed switch in sensory function during recall from a pattern of deactivation under placebo to a pattern of activation under psilocybin may explain why memories can be felt as especially vivid or ‘real’ under psychedelics.

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Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology.

January 19, 2011 Beckley Science in the Media

Authors: Bhattacharyya S, Morrison PD, Fusar-Poli P, Martin-Santos R, Borgwardt S, Winton-Brown T, Nosarti C, O’ Carroll CM, Seal M, Allen P, Mehta MA, Stone JM, Tunstall N, Giampietro V, Kapur S, Murray RM, Zuardi AW, Crippa JA, Atakan Z, McGuire PK. Neuropsychopharmacology. 2010 Feb;35(3):764-74. Abstract Delta-9-tetrahydrocannabinol (Delta-9-THC) and Cannabidiol (CBD), the two main ingredients […]

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Does intravenous {Delta}9-tetrahydrocannabinol increase dopamine release? A SPET study.

January 19, 2011 Beckley Science in the Media

Authors: Barkus E, Morrison PD, Vuletic D, Dickson J, Ell PJ, Pilowsky LS, Brenneisen R, Holt DW, Powell J, Kapur S, Murray RM. J Psychopharmacol. 2010 Sep 17. [Epub ahead of print] Abstract Intravenous (IV) Δ9-tetrahydrocannabinol (THC) induces transient psychotic symptoms in healthy subjects and in schizophrenic patients, but the psychotomimetic mechanism is unknown. One […]

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Disruption of Frontal Theta Coherence by Δ(9)-Tetrahydrocannabinol is Associated with Positive Psychotic Symptoms.

January 19, 2011 Beckley Science in the Media

Authors: Morrison PD, Nottage J, Stone JM, Bhattacharyya S, Tunstall N, Brenneisen R, Holt D, Wilson D, Sumich A, McGuire P, Murray RM, Kapur S, Ffytche DH. The Biomedical Research Centre, Institute of Psychiatry, King’s College London, Denmark Hill, UK. Neuropsychopharmacology. 2010 Dec 8 Abstract The main ingredient in cannabis, Δ(9)-tetrahydrocannabinol (THC), can elicit acute […]

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